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'Anger Management 3' was due to begin in Germany next month, including a highly-anticipated three gigs in the UK.
"Eminem is currently being treated for exhaustion, complicated by other medical issues," explained record company Interscope in a statement today.
His 23-date US tour ended in Detroit on Saturday.
A UK spokesperson told the NME: "Eminem is disappointed he won’t be able to come over to see his UK fans, and it’s unfortunate he’s had to cancel."
The dates are unlikely to be rescheduled.
