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The actor has said that he is keen to pursue more challenging roles, as well as being committed to spending more time with his family.
He told Dark Horizons, "Spider-Man 3 might be a good place to stop - I am not tied contractually to any more Spider-Man movies.
"I am not completely closed to the idea of another one if it made sense but I would say that the odds were in favour of this being the last one."
His co-star Kirsten Dunst has also expressed a desire to move on from the franchise, even mentioning aspirations to go back to university.
She said, "I'm not the type of actress who does movie after movie."
