The actor launched the Awareness Day race, which celebrated the silver jubilee of the country's Narcotics Control Bureau.
He told followers on Twitter: "Just flagged of a great initiative by the Narcotics Control Bureau - say no to drugs! They're doing great work in helping educate people."
Bachchan's forthcoming film Dum Daro Dum is about the Goan party scene and is set to feature a segment wherein the actor showcases his rap skills.
The film also stars Bipasha Basu and will see Deepika Padukone performing an item number.