The film's box office failure has sparked rumours that she is not keen to pair up again on screen with the South Indian star.
Basu told followers on Twitter: "I detest vicious Gossip! @ActorMadhavan is one of my most favourite co-stars and I would love to work with him on a film which we both like and suit.
"Power of writing should not be misused to that extent to create gossip which makes people sound shallow and nasty! Even if its a tabloid news. (sic)"
She tweeted to Madhavan: "Equations go Bad bcoz of these insensitive gossip diggers! As if Bashing ppl is nt enough Now Malign them too! Sad state!"
In February, the actress claimed that she and her co-star hit it off "straight away".
However, she said that it had been uncomfortable kissing Madhavan on screen.