The nine-day festival will be hosted by Tongues on Fire and will feature film screenings, interviews, lectures and discussions around South Asian film.
A statement on the festival's website read: "The amazing Abhishek Bachchan will be travelling to London to open the festival on 16 March. We are so excited!
"Abhishek and Meera Syal will be opening the Festival by doing the ceremonial lamp lighting with us at BFI [the British Film Institute]."
The actor is expected to attend the opening press conference and will also be present at the introduction to the opening film of the festival Michael, starring Naseeruddin Shah.
The festival honours a range of exciting films influenced by South Asian cultures that have made waves in the international film festival circuit.
Some of the major highlights of the festival are a Pakistani section in which the controversial film Bol will be screened on March 18.
Bollywood director Sanjay Leela Bhansali will deliver the Nargis Dutt lecture at the University of Westminster on March 22 and will be screening his critically acclaimed films Black and Guzaarish during the event.
The festival runs from March 16 until March 24.