The actor hosted the first and second seasons. Shah Rukh Khan took over for the third season, but Bachchan was reinstated as host for the fourth and fifth runs of the show.
KBC, which airs on Sony Entertainment Television, is the Indian version of the UK gameshow Who Wants to Be a Millionaire?.
Writing on Twitter, the 69-year-old said: "Off for a meet with Sony for next KBC... planning, operation, execution... will keep you informed on its broadcast and other details."
The Paa star underwent abdominal surgery in February and was advised rest for some time. There were reports that he may not host the show due to health issues.
The first season of Kaun Banega Crorepati, which aired in 2000, was Bachchan's debut appearance on television as an anchor.
He has revealed that when he first considered hosting the show, he was advised by friends and family that TV would be a mistake".