Kaif, who stars with Khan in Ek Tha Tiger, reportedly dated the actor when she started off her career in Bollywood, but they later separated.
Speaking to PTI, she said: "When we start working for a movie, we go in as professionals. I am here to do my job, and if people want to highlight baseless stories then it's up to them. I don't think that these stories will have any affect on my work and the film.
"I am never bothered about such stories. Why should I? I think it's what every actor goes through. When you start working in the industry, people talking about you becomes a part of your life. Why analyse it so much?"
The 27-year-old actress, who first starred alongside Khan in Maine Pyaar Kyun Kiya, also revealed that she is excited to work with him again.
"I am excited about the film, it's shaping up good. Salman is working with Yash Raj for the first time and it's my second film with them. It's always fun working with Salman, he makes everything very comfortable on the sets," she added.
Katrina is also shooting for Yash Raj Films with Shah Rukh Khan. The untitled film will mark the comeback of veteran director Yash Chopra after a gap of eight years.
"I am enjoying working with Shah Rukh and Yashji. Yashji is a living legend in Indian cinema, and working with him has been a learning experience for me. I am very fortunate to have got an opportunity to work with him. Working with him is magical.
"And Shah Rukh is a wonderful co-star. I have learnt so much from him," she said.
The Namaste London star also said that she has always been experimental with her choice of roles.
"I like experimenting with my roles. If you stick to one thing, you can easily get bored. Everything in life is a risk, there is no definite way to success," she said.
"Today, if I do a role which I have done before, there is no guarantee that the audience will like it. The higher the risk the greater will be the outcome. You won't be able to work if you fear taking risk. I just try to give my best."