The film featured Vidya Balan in the central role as a heavily pregnant woman searching for her missing husband.
Director Sujoy Ghosh told DNA India: "The talks are on with them... So we can't say anything. It is all in [the] initial stage.
"We would be happy if it is made in English. It will be great. But if it does not happen then also it is okay."
Saswata Chatterjee played the popular character of contract killer Bob Biswas.
Ghosh added: "I know people want to see more of Bob Biswas. But we can't make a prequel particularly only for Bob. His character was small and it will not make a full film."
In April, it was reported that Balan is set to embark on her first world tour after the back-to-back hits Kahaani and The Dirty Picture.
The actress said prior to its release that she expected it to be successful because the storyline is compelling.