The actor-turned-producer appeared in the previous season of Bigg Boss presented by Sanjay Dutt, but was unable to do it on his own because of his health problems.
A source told Mid Day: "Even though Salman is presently shooting in Thailand for a film with Katrina Kaif, the makers have already sounded him about being part of the new season as well. He has agreed to host it. He alone will be the host for the sixth season."
However, it is expected that the show will not air until other film star-led reality shows have been broadcast.
"The dance reality show which has Madhuri Dixit, Karan Johar and Remo Fernandes as judges will go on air first followed by a talent hunt show," the insider said. "Only then will Bigg Boss air."
Khan recently told fans to watch his friend Aamir Khan's debut documentary drama Satyamev Jayate .
His ex-girlfriend Katrina Kaif said earlier this month that she is unable to choose a favourite Khan out of the famous three actors.