The 34-year-old star can be seen in Aiyyaa playing a Marathi girl who falls in love with a mysterious man's scent.
She told The Times of India: "I think actresses too can continue working all their lives if they are willing to change with the times. Today if I am doing fewer films, it's because I choose to do less.
"My audience understands the kind of cinema I do and they follow my work closely. Nothing in the world can tempt me to do inconsequential films because if I do that I will only be offered those.
"I choose my films carefully and I repeat that's the reason why my audience gets excited with the cinema I associate myself with."
Mukerji was reportedly lined up to star in the action film Dhoom 3 opposite Aamir Khan earlier this year.
She is said to have turned down a role in Once Upon a Time in Mumbai because the film starred Emraan Hashmi.