Ghosh, who directed Bachchan in Aladin, is reportedly keen to work with the veteran actor on the eagerly awaited sequel.
Speaking to IANS, Ghosh said: "Yes, I can assure you that Amitabh Bachchan will be part of Kahaani 2 in some way or the other. His blessings matter a lot to me. I can't see myself making any films without him."
The film is a continuation of the original story in which Vidya Balan played a pregnant woman who returns to India in search of her husband. The National Award-winning actress will reprise her character and is expected to undertake more action sequences in the follow-up.
"Yes, I am planning to make her [Balan] do some action sequence in Kahaani 2 but let's see how things shape up. It's going to be challenging for me to prove myself again, but I am not thinking about that at all. I am just hoping for the best," explained Ghosh.
Made for Rs.8 crore, the film was the surprise hit of 2012, grossing Rs.80 crore at the box office and has won accolades for Balan. The film most recently won the 'Best Film' critics award at the Zee Cine Awards in Mumbai.
Bachchan, who recorded the song 'Ekla Chalo Re' for Kahaani, described the film as a "wonderfully gripping story".
Shooting for Kahaani 2 will begin in a month. Meanwhile, it has been reported that Kahaani could be remade for English-speaking audiences.