The promo introduces the three protagonists of the film, who become caught in a love triangle.
The movie stars John Abraham as Ishaan, a charismatic but self-absorbed music producer from Mumbai, who takes the people he loves the most for granted.
When Ishaan's world falls apart, he turns to neighbour Gauri to teach him the importance of relationships.
Described as a feelgood film, I, Me, Aur Main stars Prachi Desai and Inkaar star Chitrangada Singh.
The film features a song sequence starring the three actors based on a song from Chaalbaaz.
Abraham, who turned producer for Vicky Donor, said last year that he plans to make films for young people after the success of his debut production about a sperm donor.
The Race 2 star is said to be planning to buy a production company in London.
I, Me, Aur Main releases in cinemas on March 1, 2013.