The Bollywood star has announced his involvement in Dr Cabbie, starring The Big Bang Theory actor Kunal Nayyar, reports Reuters.
"Dr Cabbie is the story of an Indian immigrant and it has an inherent universal appeal," Khan said in a statement.
The film focuses on an unemployed doctor-turned-taxi driver, who becomes a local hero when he converts the cab into a mobile clinic.
It also stars Speedy Singhs actor Vinay Virmani, Outsourced star Rizwan Manji and Adrianne Palicki.
Katrina Kaif's younger sister Isabelle Kaif is also rumoured to be making her big screen debut in the project.
The first schedule of the Jean Francois Poulio-directed film began in Toronto earlier this week.
Dr Cabbie is expected to release in 2014.