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Annie Mac will take over Sara Cox's weekend afternoon show on Radio 1 while Cox is on maternity leave.
Macmanus' first weekend show will be on February 23, and she will continue to present Annie Mac's Mash Up on Friday nights. Cox will return to the station in September.
"I am delighted to look after Sara's show for her when she's having baby number two," said Annie Mac. "I think Sara is an exceptional presenter, and I just hope I do her show justice for her when she's away."
Sound co-presenter Nick Grimshaw will take over Switch on Sunday evenings when Annie Mac moves to the afternoon slot.
"Everyone at Radio 1 wishes Sara all the best and we look forward to welcoming her back after her maternity leave," said Ben Cooper, head of programmes at Radio 1. "I'm very pleased that Annie is going to look after the show while Sara is away, she's a great broadcaster and I know she'll do a brilliant job. Nick has proven himself as part of the Radio 1 family and it's very exciting that he'll be hosting his own show during this period."
