DC Comics executive editor Dan DiDio revealed that DC Universe: Legends will be set in the same world as the game.
He told IGN that writers Tony Bedard and Dan Jurgens were already on board the project and he expected Marv Wolfman, who has helped Sony develop the game, to be involved on some level.
DiDio said: "Well, there are a number of things that are going to go on. First, we're going to set up the conceit of the universe, how it works and what the rules are.
"We'll also be trying to work gaming tips and secrets into the body of the book as we move along in the series. You'll see a lot of support material including turnarounds and designs that went into the actual building of the game.
"What I think is the most exciting thing is that, if everything is working as well as we hope once we get down the line, characters that players create actually have an opportunity to work their way from the game into the comics themselves."
DC Universe Online and DC Universe: Legends are due for release sometime this year.