According to the illustrator, the book's first arc 'Xenogenesis' will explore the science fiction side of the X-Universe. Written by Warren Ellis, the plotline will run for five issues.
"A question Warren is asking with this series is, 'What does it mean to be a mutant?'" Andrews told CBR. "We've investigated that question however many times philosophically, but this is more like answering it biologically.
"What does it mean to be a mutant, and is that changing? And if it is changing, how would the X-Men react to those changes? Warren is such an idea man. You can turn off his ideas. They infect things, so I'm happy to play around with some of his big concepts."
The artist also revealed that fans can expect to see the "classic" incarnations of the mutant team in the comic. "Some of the things I drew on for this X book were that I wanted it to be clean. I wanted it to be more clean than my more sloppy stuff in the past. I wanted open lines and textured colours. I wanted it to be brighter," he added.
Astonishing X-Men: Xenogenesis launches in May.