DC Comics has yet to reveal when Simone will leave the book or who will replace her, but she confirmed that she would be contributing to June's renumbered Wonder Woman #600.
Posting on the publisher's The Source blog, Simone said: "Working on Wonder Woman has been one of the most thrilling things in my career.
"There aren’t many jobs in comics as cool as writing dialogue for Hippolyta as she’s riding a flying horse and stabbing giant sea monsters. I had a blast and as always when I leave a book, I’m going to miss the cast terribly."
Of her other projects, Simone added: "I’m doing books that make me happy every day, like the incredibly fun and horrid Secret Six, which has some really shocking surprises coming, and then of course a book very dear to my heart, the return of Birds Of Prey in May, with artist Ed Benes doing the finest work of his career.
"And I can announce for the first time officially, a really exciting Welcome To Tranquility mini-series starts in July."