The 30 Days of Night writer will be joined by artist Ashley Wood (World War Robot) on the project.
The series follows Nick Hammond and Anastasia Collins, a pair of underground investigators who uncover sinister conspiracies perpetrated by the authorities.
"This book is a conspiracy theorist-cum-monster fan's dream!" said IDW senior editor Bob Schreck.
"Steve and Ashley's concept 'Brundle-Flies' Nick and Nora from The Thin Man with a sort of Scully and Mulder from The X-Files as this well-to-do duo run the gamut exposing the truth behind 'real life' conspiracies and all things that go bump in the night."
Mystery Society will debut in May.