Cable was seen enabling his teammates to reach safety before finally succumbing to the techno-organic virus that the character had suffered from for much of his existence.
"For us, Cable was always a character whose death was something the character himself would put forward - if that's what it took to complete his mission," Yost told Newsarama.
"When he sacrificed himself saving X-Force, the last thing he saw was that Hope [Summers] had survived... and he could finally let go," he continued.
Kyle and Yost have written two significant deaths so far in X-Men crossover Second Coming, with long-time X-Men stalwart Nightcrawler being killed off earlier in the storyline.
Cable originally appeared in the X-Men teen series New Mutants before moving on to lead the militant squad X-Force throughout the 1990s.
Cable's role in the Marvel Universe had evolved significantly over the past two years, as he became a protector and father figure to new character Hope Summers, who is destined to be a messiah-like figure in Second Coming.