Pekar lived in Cleveland, OH for most of his life and began his famed title in 1976 as a self-published piece of work which chronicled the life of its file clerk protagonist (based on Pekar himself).
Although American Splendor was mostly self-distributed by Pekar, in 1994 it began being published by Dark Horse and in 2006 DC Comics' imprint Vertigo published an American Splendor miniseries.
In 2003, the series was adapted into a film written and directed by Shari Springer Berman and Robert Pulcini which starred Paul Giamatti as Harvey Pekar.
The film, also called American Splendor, was nominated for an Academy Award for 'Best Adapted Screenplay' and received positive reviews from critics.
CBR reports that Pekar was found dead by his wife early this morning. The cause of death is unknown at this stage.