During the publisher's panel at Comic-Con, senior story editor Ian Sattler confirmed that the 1970s title will make a comeback early next year.
According to CBR, Justice League: Generation Lost artist Aaron Lopresti is "heavily involved" with the project and his creator-owned character Garbage Man will feature in its pages.
"Those readers who are as old as me, [DC co-publisher] Dan DiDio and [editor] Joey Cavalieri might remember in the early '70s that DC had an anthology book called Weird Worlds that featured a lot of Edgar Rice Burroughs material like John Carter Of Mars and Carson Of Venus," Lopresti said.
"We are bringing that back as a launching place for new characters and material, some of which will be creator-owned but still fit within the DCU."
The illustrator also hinted that Batman could make a guest appearance in the Garbage Man feature. "The story starts outside of Gotham City so expect to see a rather prominent DC character sticking his nose into Garbage Man's affairs," he added.
Weird Worlds debuts in January 2011.