It was revealed at Comic-Con International that the legendary comics creator will pick up where the series left off in 1995.
Originally published by Dark Horse, the comic, which follows the attempts of a secret project to create superhumans, has been collected by IDW.
"When John started working for us three or four years ago, two things happened, and have been happening pretty much every month since then," said IDW editor-in-chief Chris Ryall.
"I've been asking John about doing new Next Men comics, and fans have been e-mailing me demanding that we do new Next Men stories. Happily, after all this time, John is going to quiet us all down and do just that."
The series will return in December, with Byrne pick up after the cliffhanger ending of issue #30 he wrote in 1995.