Based on a multi-dimensional zombie outbreak, the series will tie in with the publisher's Star Trek, Transformers, G.I. Joe and Ghostbusters comics.
Written by Dan Abnett and Andy Lanning with artwork by David Messina, the storyline will begin in IDW's Zombies vs Robots universe before branching out into alternate planes.
"This is definitely one of those 'there's no way they'll ever do this' kind of events," said IDW’s chief creative officer Chris Ryall.
"But not only are we doing something fans never thought they'd see, we're doing it in a way that should confound and exceed their expectations. And doing it with real pros like Abnett and Lanning just makes it that much sweeter, especially knowing what they've got planned as a follow-up to this event."
The event kicks off with The Infestation #1 in January 2011. It will continue with issues based on each of the firm's film licences throughout the year.