Debuting as a 'Pilot Season' short in 2008, the comic follows a young female military genius who becomes embroiled in a gang war in South Los Angeles.
Written by Marc Bernardin and Adam Freeman, the original strip featured artwork by Afua Richardson. The entire creative team will return for the new series.
"For my part, it came from a decent amount of late-night History Channel viewing. Watching documentaries about Alexander the Great or Ghengis Khan or Sun Tzu, men for whom combat and military strategy came as second nature," Bernardin told Newsarama.
"Then watching documentaries about American militias and listening them taking about arming themselves for the impending race war... what if the person they were most afraid of was a little girl?"
Freeman added: "We combined that with my fascination with child prodigies. We have seen pre-schoolers with unexplainable gifts whether it is mathematics or the violin. How do we know there is not an undiscovered phenom out there with prodigious tactical and strategic ability?"
Genius is expected to arrive in early 2011.