Jason Aaron relaunched the series last year and the title has received critical acclaim for its initial story arc, which sees Wolverine's mind sent to Hell while his body remains on Earth possessed by a demon.
"Now his mind and body have been hijacked once again, and he'll be forced to pull off the ultimate assassination," Marvel's press release reads. "Find out who truly is the most dangerous mutant of all as Weapon X stalks the Children of the Atom."
The issue also sees comic book artist Daniel Acuna join Aaron on the series as the new regular penciller.
Wolverine #6 will be published on February 16.