Throne of Blood: Birth of a Vampire will be written by Victor Gischler and illustrated by Goran Parlov.
The image shows an unidentified vampire standing before a trophy wall where some of the Marvel Universe's most recognisable relics hang,
"A game changer in 'Fear Itself' stands revealed," said Marvel. "He will leave the Marvel Universe a different place. His story begins here.
"Thought you knew everything about vampires? Don't be so sure. You'll never look at vampires the same way ever again."
Last year, Gischler wrote both the Death of Dracula one-shot and the vampire-featuring 'Curse of the Mutants' storyline in X-Men.
Throne of Blood: Birth of a Vampire will be released on April 6.