Kicking off in May, the scheme will spotlight new comics featuring Moon Knight, Daredevil and the Punisher.
Brian Michael Bendis and Alex Maleev's Moon Knight #1 is to be the first title launched under the banner. The Punisher #1 will follow in June, before Daredevil #1 rounds off the promotion in July.
"Fans are going to love what we have in store with 'Big Shots'," said Marvel editor-in-chief Axel Alonso. "We're taking some of the best Marvel characters that we all know and love and sending them in a brand new direction with some Grade A talent.
"We want to reach a whole new set of readers while at the same time appeal to longtime fans of these great heroes and 'Big Shots' is how we're doing it."
Creative teams for the Daredevil and Punisher titles are expected to be announced soon.