Written by Dan Slott and illustrated by Humberto Ramos, the event kicks off with a prelude in Amazing Spider-Man #666 this summer.
The story sees the inhabitants of Manhattan - including the hero's allies and enemies - exhibit spider powers themselves. Spider-Man must uncover who is behind the mass mutation and prevent it from spreading further.
"Back when Slott launched Spider-Man into the 'Big Time' last year, he started laying the groundwork for possibly the biggest Spider-Man story you've ever seen," said Marvel senior editor Stephen Wacker.
"The price of power is high for heroes and villains. The Avengers, the FF, Venom, Spider-Girl, Spider-Woman, the Sinister Six and even you are connected to ol' Web-Head in new ways. By the end of this story, we're going to see what Spider-Man means to Marvel Universe and just how far he'll go to keep it safe... including some life-changing choices that have major consequences."
Slott was unveiled as the sole writer on Amazing Spider-Man at last summer's Comic-Con International. The writer has already completed two arcs on the title.
'Spider-Island' officially begins in issue #667 in August.
> Slott excited about Spider-Man family
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