Current series writer Ed Brubaker and Civil War artist Steve McNIven have been unveiled as the creative team behind the upcoming relaunch.
Captain America #1 will see Steve Rogers retake on the mantle of Captain America in a new ongoing series, launching this July to coincide with the release of Captain America: The First Avenger.
Marvel's press release for the relaunch reads: "Steve Rogers is back as Captain America but when a mysterious figure from his past returns with the Sentinel of Liberty in his crosshairs, deadly secrets will surface and send shockwaves through the lives of everyone Steve holds dear."
Brubaker explained: "I gave myself a few challenges for this new #1 - I wanted to do the perfect Cap comic for anyone who walks out of the Cap movie and wants to know what's next, but it also had to build on everything I've done on the book beforehand, too, and feel like the natural next step."
The company recently celebrated 70 years of the character in Captain America #616.
Captain America launches with a special oversized first issue in July.
Watch the trailer for the upcoming Marvel Studios film Captain America: The First Avenger below: