It's Dark in London will feature work by the two legendary writers, alongside other talent including Gaiman's long-time Sandman collaborator Dave McKean, Moore's wife Melinda Gebbie, Carol Swain, Iain Sinclair and Stella Duffy.
"This fusion produces a portrait of London that captures the city's fundamental essence as an exquisite mixture of lofty towers and gutter sleaze, of suburban gentility and urban depravity, of private vices and public philanthropy," said the publisher.
The black and white short story collection will be edited by London-based, Argentinian illustrator Oscar Zarate, who worked with Moore on A Small Killing.
Gaiman's work includes Neverwhere, a novel that explores the hidden world beneath London and amongst its rooftops. It began life as a 1996 BBC Two television series.
His Doctor Who episode, entitled 'The Doctor's Wife', is due to air in the UK and the US in May.
It's Dark in London will be released in April 2012.
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