The extra-sized issue features the writing debut of Dan Abnett and Andy Lanning, who are collectively known as DnA, on the series. It also sees the return of Nate Grey to the pages of the X-Books.
"Whatever happened to X-Man?" said the publisher. "Cyclops needs to know and he's enlisted the New Mutants to locate and capture Nate Grey - by any means necessary! But after being manipulated at the hands of Norman Osborn, just what has become of the unstoppable X-Man... and how far will he go to stay unfound?
"The hunt for the Marvel Universe's most powerful mutant begins this May, only in New Mutants #25."
Grey is an alternate reality version of the hero Cable, starring in the X-Man title. He died and was resurrected during 'Dark Reign' in the Dark X-Men miniseries.
The Leandro Fernandez-illustrated New Mutants #25 was teased as a part of MMXI.
It will be released on May 11.