52 first issues will be released following the conclusion of the current event.
The DC titles will also all go day-and-date with their print and digital releases.
August 31 will see the release of only two comics by the publisher - the concluding Flashpoint #5 and the debut issue of a new Justice League title by Geoff Johns and Jim Lee.
The changes to the line will include rebooted character origins and costume redesigns by Lee.
"We looked at what was going on in the marketplace and felt we really want to inject new life in our characters and line," co-publisher Dan DiDio told USA Today. "This was a chance to start, not at the beginning, but at a point where our characters are younger and the stories are being told for today's audience."
New ongoing series will include a Superman title penned by Grant Morrison, Teen Titans from Fabian Nicieza, Hawkman by James Robinson and Aquaman from Johns and Ivan Reis.
Johns will also continue on Green Lantern but Birds of Prey #1 will not be written by long-time scribe Gail Simone.
It had already been confirmed that Johns would no longer be writing The Flash after 'Flashpoint'.