The long-running series, which has maintained continuity since the 1960s, is to end with issue #544 due to the events of the 'Schism' story arc.
"The X-Men are getting torn apart from within. The events of 'Schism' do more damage to the X-Men than any villain has ever done," editor Nick Lowe told The AP.
Marvel's solicitation for the book's final issue reads: "All things must come an end… even for the X-Men, and this October fans will bear witness the end of an era as Uncanny X-Men #544 concludes the long-running series.
"It's all come to this! Years in the making, the seeds of dissent finally bear fruit as the events of X-Men: Schism tear the X-Men and the Marvel Universe apart! When the dust settles, the state of mutantkind will irreparably be changed forever."
Uncanny X-Men #544 is written by Kieron Gillen and illustrated by Gregg Land. The issue arrives in stores in October.
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