IDW Publishing is releasing Cold War, a period piece starring former MI6 agent-turned-freelance operative Michael Swann, reports The AP.
"He operates on a freelance basis, and occasionally his former bosses call upon him to handle something that is perhaps a bit too messy for Her Majesty's Government to be involved with," said Byrne.
"So he knows that when he is called upon, things have reached some dire straits. His response to this is usually very straightforward and brutal."
Byrne spoke more about Cold War on his forum.
"Although set in the early days of the Cold War, this is NOT going to be a history book," he wrote.
"I am playing quite freely with the order in which things happened in the real world. And I will not be tying Swann's exploits to any specific year or sequence of years.
"Those with an awareness of the history of this period may spot a few landmarks - one in most particular plays an important part as a sub-thread to my overall tale - but no reason to start checking the History Channel in order to be able to follow what's going on in this series."
Byrne has previously worked on major Marvel Comics titles including X-Men, Fantastic Four and Alpha Flight, and was responsible for DC Comics' acclaimed retelling of Superman's origin in The Man of Steel.
IDW is also publishing Byrne's Next Men, which he recently returned to after a long hiatus.
Cold War will be written and illustrated by Byrne with colours by Ronda Pattison.