Matt Fraction and Terry Dodson's new comic will spin out of the 'Fear Itself' event, and will bring together a team featuring Iron Fist, Namor, Red She-Hulk, Silver Surfer and Doctor Strange.
"The Hulk needs a favour and he goes to people he feels owe him," Fraction told Comic Book Resources. "That happens to be the some of the people you and I know as the Defenders.
"It's not necessarily a pleasant reunion. It's not a comfortable one. There are a lot of grudges because of some recent history, but the awkward truth of it all is Hulk needs help, which is never an easy thing to ask for, especially if you're him. Red She-Hulk quickly comes along. So does, for reasons to be revealed, Iron Fist."
The series sheds light on a recent series of teasers released by Marvel featuring silhouettes of the Defenders' various members.
Fraction continued: "They're very much the most Marvel of Marvel teams. They're the most freaky, the most weird, and the biggest loners. They're literally brought together by secrets. So we can mine that pathos for good comics."
Defenders was announced during the 'Fear Itself' panel at Comic-Con. It will debut in December.