The Image Comics supernatural miniseries will debut in January.
The writer and artist is best known as one half of the Luna Brothers, working alongside his brother Jonathan.
The story follows the tale of Sam Webber, a man suffering from severe obsessive-compulsive disorder who discovers that he has the ability to travel outside of his body in a spectral form.
"What's funny is that I've been working in the comic industry for seven years now, but taking on a book myself feels like I'm starting all over again," Luna told Comic Book Resources.
"Throughout our collaboration on our books, we would constantly edit or approve each other's work. There was a constant back and forth. After seven years of that process, it's interesting to finish a script or a page and realise it's coming from me, then directly to the reader. No stops. No-one else to blame, but me. Kind of a scary thought."
Whispers explores the concepts of free will and control.
The Luna Brothers have produced some of their best known titles for Image, including Ultra, Girls and The Sword.