The Fantastic Four #600 and FF #12 teaser shows the Devourer of Worlds standing in a crater on what appears to be the moon.
"Very soon, your world is going to be broken," reads the caption.
Fantastic Four will return with the milestone issue after a hiatus following the apparent death of the Human Torch in the 'Three' storyline.
Jonathan Hickman will continue to write both ongoing series, with Steve Epting illustrating Fantastic Four and Juan Bobillo providing art for FF.
Leinil Yu, Carmine Di Giandomenico, Farel Dalrymple and Ming Doyle will also provide guest artwork for the 600th issue.
Previous teasers for the upcoming storyline have featured Doctor Doom and the young Franklin Richards.
Galactus is one of the team's most well-known enemies, first debuting in Stan Lee and Jack Kirby's legendary first run on Fantastic Four.
Fantastic Four #600 will be released on November 22 and FF #12 will debut on November 30.