Titles launched under the imprint will be available to download for computers and mobile devices on the same day that their print counterparts arrive in stores.
The publisher announced the initiative at last weekend's New York Comic Con, confirming that this week's edition of Sweet Tooth will kick off the venture. Subsequent titles including Fables, American Vampire and Hellblazer will also switch to the business model.
"We've found digital to be a great way to bring in new audiences and I'm excited to introduce digital comic readers to these already very popular Vertigo titles," said Hank Kanalz, DC's senior vice president of digital.
DC's core imprint switched to the day-and-date digital model as part of its 'New 52' relaunch, which began on August 31 with the release of Justice League #1.
Marvel Comics also made strides in the sector at the New York convention, announcing that its Season One line of graphic novels will be released simultaneously in digital and print.