It will be written by Ande Parks with art by Esteve Pols, who worked on Dynamite's The Lone Ranger: The Death of Zorro miniseries.
The title will begin with a six-part story called 'Hard Country', which sees the Lone Ranger - aka John Reid - and Tonto struggling out into the lawless Wild West.
"The Lone Ranger #1 begins our 'Hard Country' arc with a heart-breaking tale of loss that holds a mirror up to John Reid's past," said Parks.
"The man John Reid has become in his The Lone Ranger identity was shaped by tragic loss. Now he sees that loss on the faces of a new generation. Can one man make a difference in the lives of a father and his children whose world is crumbling? The Lone Ranger is damn well going to try!"
Legendary artist Alex Ross will provide a painted cover for the first issue, with Franco Francavilla serving as ongoing cover artist.
Dynamite has recently announced a string of classic licensed series, including Flash Gordon and The Shadow.