The five-issue miniseries sees the return of the writer's Dancy Flammarion character.
Kiernan has said that the series will feature a version of Flammarion that has made some different decisions from her earlier, prose story incarnation.
"I don't want to risk spoilers. Too much of what's going to be good about Wolves is the new path Dancy is set upon, and how that messes her up, the consequences of her actions, the characters she encounters," Kiernan told Comic Book Resources.
"For me, it's a prelude to the Dark Horse stories that will follow Wolves. But, I can say, she's up against a South Carolina swamp haunted by a pack of werewolves, and, ultimately, far worse things than werewolves. And she learns her weaknesses in a way she never has before.
"She's becoming less that avenging hand of god. And, quite against her wishes, she ends up with two strange and unlikely travelling companions."
Flammarion is a young albino woman who hunts monsters with her (possibly imaginary) seraph companion in the Southern United States.
Kiernan previously wrote for The Dreaming and other Sandman spinoff titles, which she described as "a very unpleasant experience" and "creative nightmare".
Dark Horse had previously teased the return of Flammarion.
The series will debut in Dark Horse Presents #9 on February 22 before Alabaster: Wolves #1 is released on April 11.
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