The publisher released a Ryan Stegman illustration of Kaine wearing the mantle of the superhero, ahead of the comic's debut next month.
Scarlet Spider #1 is written by Chris Yost and drawn by Stegman. The title spins out of the recent 'Spider Island' event, and sees Kaine take on a crime syndicate in New York City.
"Scarlet Spider is a book that can deal with a character much like Peter Parker but at a darker, more difficult place in his life," said Stephen Wacker, Marvel senior editor.
"The violent choices he's made through years of struggle - the sins of youth, so to speak - have come at a brutal cost. He may hope that the things he's done will be left to the dusty, yellowed pages of history, but someone ALWAYS remembers who you used to be."
Scarlet Spider #1 is released on January 4, 2012.