The legendary comics writer urged people who wish to give him a present for his 89th birthday to 'shift their gifts' to the not-for-profit organisation.
Lee said: "A gift to Hero is like a thank you note to every comic book creator who ever brought you countless hours of fun, thrills and unforgettable reading enjoyment.
"It's a great way to celebrate any birthday - especially my own!"
The Hero Initiative charity supports comics creators with "medical aid, financial support for essentials of life, and an avenue back into paying work".
Donations can be made through the ShiftMyGift website.
Lee created some of Marvel Comics' most iconic characters, including Spider-Man, the Fantastic Four and the X-Men.
He will celebrate his 89th birthday on December 28.
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