The guitarist will portray a character described by writer Llexi Leon as a "cryptic entity" with "limitless knowledge and incredible power".
Eternal Descent is a science fiction title inspired by music from various artists. It has previously featured cameos from bands such as Static X and God Forbid. Satriani is actively involved in the creative process.
"The way I look at things, real life is crazier than comics, Science fiction provides focus for the dreams and aspirations of forward thinking people," he told Newsarama.
"Comics like Eternal Descent give it a look and a vibe that can act as a catalyst for some very creative imagining of our future."
Satriani will appear in Eternal Descent #3, slated for February next year.
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