The book collects Brian Wood's out-of-print series, which were originally published by Image Comics.
This included Jennie One, which features art by his frequent collaborator Becky Cloonan.
"Channel Zero is literally the start of my comics career, the first proper comic I ever made, and as such as informed everything that's come after it, especially DMZ and the upcoming The Massive," said Wood.
"It also put me and Becky Cloonan together, helping build a creative partnership that has lasted a decade. This edition here is the definitive one, including everything worth printing, including a colour section that includes the original covers to the single issues."
The book collects the original 1997 graphic novel, Jennie One, the best of the two Public Domain design books, a host of extras, rarities, short stories and unused art, and an introduction from Warren Ellis.
Wood and Cloonan are currently collaborating on Dark Horse's Conan: Queen of the Black Coast.
Channel Zero: The Complete Collection will be released on May 30.