The B.P.R.D. writer's three-part suicide mystery will debut in the Dark Horse Presents #11 anthology.
"In the summer of 1987, a young teenage boy commits suicide," said the publisher.
"The boy's mother is unsatisfied with the police's lack of interest in the motivation behind it, or what connection it might have to the suicide of the boy's former best friend.
"She remembers that she heard an old college boyfriend of hers, Oxel, is a private detective. What she doesn't know is Oxel suffers from a debilitating condition called acromegaly. Will the contact from his old flame be all that Oxel needs to take the case?"
Jonathan Case will provide the artwork for the story.
In 2012, Arcudi will continue to work on Mike Mignola's Hellboy spinoff, with five new B.P.R.D. titles unveiled for the year.
DC Comics has announced the reprinting of the writer's short-lived series Major Bummer, which was illustrated by Doug Mahnke.
Dark Horse Presents #11 will debut on April 18.