Spider-Man, Daredevil and The Punisher will collide in the storyline, which launches in April.
The story will spin out of Daredevil's possession of the so-called 'Omega Drive' in Mark Waid's ongoing series.
"Daredevil has basically conned five of the biggest crime communities in the Marvel Universe - Hydra, AIM, Black Spectre, Secret Empire and Hidden Team - out of a unique hard drive that contains key information on all five organizations," said Waid at Marvel's Next Big Thing conference call.
"It's the hot potato that Daredevil has and it makes him the most dangerous man on Earth."
"The problem with Daredevil holding the device is that these organizations don't want anyone else to have it," said Punisher writer Greg Rucka.
"Once Frank finds out about the drive and finds out what's on it, he says, 'You know what? Give that to me'. Frank's feeling is 'I can keep it safe and I can use it properly', so one sees the conflict immediately between these two gentlemen."
Spider-Man is asked to retrieve the Drive by its inventor Reed Richards, and will have a serious run in with the trigger happy Punisher.
'The Omega Effect' will launch in April in Avenging Spider-Man #6, and continue in Daredevil #11 and Punisher #10.