The series, scheduled to debut in April, will serve as a prequel to the publisher's Flash Gordon: Zeitgeist comic, focusing on the rise of the titular villain.
Scott Beatty is writing the series, accompanied by artist Ron Adrian. Alex Ross will provide cover illustrations.
"In most heroic fiction, we (the readers, that is) never really question why the villains do very bad things. It's always just assumed that evil is as evil does," said Beatty.
"Ming is one of the great antagonists of science fiction. In many ways, he's archetypal and the model for all intergalactic despots to follow. But he's not just Ming. Everybody knows he's Ming the MERCILESS. And he's successful at being just that."
Beatty added: "Ming has a plan. For EVERYTHING. Readers of Flash Gordon can think of Merciless - The Rise Of Ming as 'required reading' for the series's central conflict.
"It's a primer that reveals not just who Ming the Merciless is - well before he ruled all of Mongo - but just what he did to get there... and WHY he did it."
Merciless - The Rise Of Ming arrives in stores in April.
> Pathfinder licence acquired by Dynamite Entertainment