The new all-ages graphic novel will be written by Nate Cosby (Jim Henson's The Storyteller) with art by Chris Eliopoulos (Franklin Richards: Son of a Genius).
The story follows the adventures of 10-year-old bounty hunter Boyd Linney as he chases down his outlaw family.
"This is my favourite thing I've ever written," said Cosby. "And it's the best thing Chris has ever drawn.
"It's an all-ages tale of justice, redemption and growing up with the knowledge that you can love your family... but that doesn't mean you can let them get away with everything. I'm so excited Archaia is giving Chris and I the chance to bring our story to a big audience."
The title will also feature short stories from Roger Langridge (Snarked!, Popeye), Colleen Coover (Spider-Man), Brian Clevinger and Scott Wegener (Atomic Robo) and Mike Maihack (Cleopatra in Space).
Cow Boy: A Boy and His Horse will be released in March. Free weekly updates will be released on cowboycomic.net from January 23.