Vandal Savage and his daughter will star in the three-issue arc, according to The Source.
Writer James Robinson (The Shade, Earth 2) and artist Bernard Chang - who worked on the first, Deadman-focused arc - will collaborate on the story.
It will centre on Savage's newly introduced daughter, top FBI profiler Kass Sage, who must enlist the help of her imprisoned father to solve a deadly crime.
Savage is an immortal villain from before the dawn of recorded history who had a hand in major historical events and tragedies through the millennia. He currently stars in Demon Knights.
It is not clear if Sage is intended to be a reboot of Secret Six member Scandal Savage or an entirely new offspring of Savage's.
The current DC Universe Presents arc features Jack Kirby's Challengers of the Unknown as interpreted by Dan DiDio and Jerry Ordway.
The Vandal Savage arc will begin in May's DC Universe Presents #9.