It unveils Peter Parker's latest armoured suit.
"He'll go to the ends of the Earth to save you," reads the caption.
Previous teasers have shown the return of the Sinister Six, a group of civilians in terrible pain and Spider-Man dressing himself in his new suit.
"The Sinister Six, led by the vengeful Doctor Octopus, is back and they're looking for revenge" said Marvel.
"Can Spider-Man and Earth's Mightiest save the world before Doc Ock's explosive endgame is revealed?"
Earlier in the week, another mysterious 'Spider-Men' teaser was released, displaying an amalgamation of the regular Spider-Man and Ultimate Spider-Man logos and sparking rumours of a crossover between the original hero and his parallel universe counterpart Miles Morales.
The story will launch in Dan Slott and Stefano Caselli's Amazing Spider-Man #682.
2012 year marks 50 years since Spider-Man's debut in Amazing Fantasy #15.